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Symbol Name ID |
Cd274
CD274 antigen MGI:1926446 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Mouse Phenotypes | immune system phenotype |
decreased T cell apoptosis |
increased T cell proliferation |
abnormal T-helper 1 cell differentiation |
decreased germinal center B cell number |
decreased plasma cell number |
decreased T helper 1 cell number |
decreased T-helper 17 cell number |
decreased CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
increased T cell number |
increased activated T cell number |
abnormal T cell morphology |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal CD8-positive, alpha beta T cell morphology |
decreased IgG1 level |
increased IgG1 level |
decreased IgG2a level |
increased IgG2c level |
abnormal T follicular helper cell physiology |
abnormal CD8-positive, alpha-beta T cell physiology |
abnormal regulatory T cell physiology |
abnormal dendritic cell physiology |
abnormal cytokine secretion |
abnormal chemokine secretion |
increased interferon-gamma secretion |
abnormal interleukin secretion |
decreased interleukin-17 secretion |
increased interleukin-4 secretion |
increased tumor necrosis factor secretion |
increased susceptibility to autoimmune disorder |
increased susceptibility to autoimmune diabetes |
increased susceptibility to experimental autoimmune encephalomyelitis |
increased susceptibility to induced arthritis |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
decreased susceptibility to Riboviria infection induced morbidity/mortality |
decreased susceptibility to parasitic infection |
decreased susceptibility to Riboviria infection |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||
| Cd274tm1.1Lex/Cd274tm1.1Lex | ||||||||||||||||||||||||||||||||||||||||
| Cd274tm1Lpc/Cd274tm1Lpc | * | |||||||||||||||||||||||||||||||||||||||
| Cd274tm1Shr/Cd274tm1Shr | ||||||||||||||||||||||||||||||||||||||||
| Cd274tm2Shr/Cd274tm2Shr | ||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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